Hydroxychloroquine (HCQ) is a medication primarily used to treat malaria and autoimmune diseases such as rheumatoid arthritis and lupus. However, it gained significant attention in early 2020 as a potential treatment for COVID-19, with some political leaders promoting it as a “miracle drug” and others dismissing it as dangerous and unproven. This controversial drug has become a subject of extensive research and debate, as well as a symbol of the scientific and political controversies surrounding COVID-19.


History of Hydroxychloroquine

HCQ is a derivative of chloroquine, a medication used to treat malaria since the 1940s. Chloroquine was discovered by German scientists in the 1930s and used extensively during World War II by Allied troops fighting in the Pacific, where malaria was prevalent. After the war, chloroquine became widely used to treat and prevent malaria worldwide, especially in Africa, Southeast Asia, and South America.

In the 1950s, researchers discovered that chloroquine and its derivative HCQ had anti-inflammatory properties and could be used to treat autoimmune diseases such as rheumatoid arthritis and lupus. HCQ was approved by the U.S. Food and Drug Administration (FDA) in 1955 and became one of the most commonly prescribed medications for autoimmune diseases.

In early 2020, HCQ gained renewed attention when some studies suggested that it might be effective in treating COVID-19, a new disease caused by the SARS-CoV-2 virus that was spreading rapidly worldwide. Some researchers hypothesized that HCQ might interfere with the virus’s ability to enter and replicate in human cells, as it had been shown to do with other viruses.


Controversy over Hydroxychloroquine and COVID-19

The controversy over HCQ and COVID-19 started when French microbiologist Didier Raoult published a small study in March 2020, claiming that HCQ and the antibiotic azithromycin were effective in treating COVID-19 patients. Raoult’s study was criticized for its small sample size, lack of randomization and blinding, and other methodological flaws. However, the study gained widespread media attention, and some political leaders, including U.S. President Donald Trump, began promoting HCQ as a potential cure for COVID-19.

As the COVID-19 pandemic continued to spread, several other studies were conducted to test the efficacy of HCQ in treating or preventing the disease. However, the results of these studies were mixed, with some showing positive effects and others showing no benefit or even harm.

One of the largest and most rigorous studies on HCQ and COVID-19 was a randomized controlled trial conducted by the World Health Organization (WHO) in several countries. The study, which included over 11,000 participants, found that HCQ did not reduce mortality or hospitalization rates among COVID-19 patients. The study was published in the New England Journal of Medicine in October 2020 and was considered a significant blow to the idea that HCQ could be an effective treatment for COVID-19.

Other studies, however, have shown more positive results for HCQ. A retrospective study conducted by researchers at the Henry Ford Health System in Michigan found that HCQ was associated with a lower mortality rate among hospitalized COVID-19 patients. The study, which was published in the International Journal of Infectious Diseases in July 2020, was criticized for its methodological limitations, but some supporters of HCQ cited it as evidence of the drug’s efficacy.

In June 2020, the FDA revoked its emergency use authorization for HCQ and chloroquine to treat COVID-19, citing concerns about the drugs’ safety and efficacy. The FDA’s decision was based on several studies, including the WHO trial, which found that HCQ did not provide any clinical benefit and could even cause serious side effects such as cardiac arrhythmias.

Despite the lack of evidence supporting HCQ’s effectiveness against COVID-19, some political leaders and groups continue to promote the drug as a treatment and even a preventative measure. This has led to a polarized debate over HCQ’s safety and efficacy, with some accusing the scientific establishment of suppressing potentially lifesaving treatments and others warning against the dangers of promoting unproven and potentially harmful remedies.

In response to the controversy, several large-scale clinical trials are ongoing to test HCQ and other drugs for COVID-19 treatment and prevention. The results of these studies are eagerly awaited by both supporters and critics of HCQ, as they could provide a definitive answer to the question of whether the drug is effective against COVID-19.

In the meantime, the debate over HCQ serves as a reminder of the complexities of developing effective treatments for new diseases and the importance of relying on rigorous scientific evidence rather than anecdotal reports or political agendas. While HCQ may have a role to play in treating malaria and autoimmune diseases, its effectiveness against COVID-19 remains unproven, and its use should be based on careful consideration of the risks and benefits.